EOMES-positive CD4+T cells are increased inPTPN22(1858T) risk allele carriers
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چکیده
منابع مشابه
Increased Risk of Hypertension in Low aged-carriers with rs2596542 Risk-allele
Background:Hypertension with its related disorders is one of the most common health problems among the Iranian population. Hypertension can be developed by chronic stress and a positive association between stress and rs2596542 has been confirmed. Methods:A Total number of 112 hypertensive patients and 97 healthy individuals were involved in the study. Total blood genomic-DNA was extracted and ...
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BACKGROUND Although several studies in various countries have indicated that the presence of the E4 allele of the apolipoprotein-E (APOE) gene is a risk factor for ischemic cerebrovascular disease, the strength of this association still remains a matter of debate. OBJECTIVES The aim of the study was to determine the frequency of the APOE E4 allele and various other gene polymorphisms in in a ...
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Together with point mutations, homozygous deletions or duplications in PARK2 are responsible for the majority of autosomal recessive juvenile Parkinsonism. It is debated, however, whether heterozygous carriers of these mutations are at increased risk of Parkinson's disease (PD). Our goal was to determine whether heterozygous carriers of copy number variants (CNVs) affecting exons of the PARK2 g...
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Strong inter- and intrafamilial variation of penetrance of breast and ovarian cancer is observed in BRCA1 mutation carriers. The wild-type copy of the BRCA1 gene is a plausible candidate as a cancer risk modifier given that the residual function corresponding to the intact BRCA1 allele may influence the process of tumor formation in BRCA1 carriers. Indeed, growing evidence is now becoming avail...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2018
ISSN: 0014-2980
DOI: 10.1002/eji.201747296